Ihorudhac
Saddex shay oo wadne-wadnaha wadnaha ah: Troponin I / Creatine Kinase Isozyme / Myoglobin (cTnI / CKMB / myo) Qalabka tijaabada
Fluorescence immunochromatography
Muhiimada caafimaad
Myoglobin waa calaamadeeyaha borotiinka wadnaha ee ugu horreeya kaas oo si aan caadi ahayn u kordho ka dib dhaawaca myocardial. Serum myo waxay bilaabataa inay korodho 2 saacadood ka dib weerarka degdega ah ee myocardial waxayna gaartaa meesha ugu sarreysa 4-6 saacadood. Maadaama myo uusan lahayn astaamo u gaar ah wadnaha myoglobin, taban ee myoglobin ayaa caawiya
laga reebo ogaanshaha AMI. Istaraatiijiyada ugu fiican ee isticmaalka calaamadeeyahan waa in la isticmaalo qiimeheeda saadaalinta xun ee sarreeya iyo dareenka si meesha looga saaro wadna xanuunka myocardial.
Troponin I hadda waa tilmaame lagu kalsoonaan karo oo loogu talagalay ogaanshaha wadnaxanuun myocardial oo leh gaar ahaan ugu sarreeya iyo muddada ugu dheer. troponin wadnaha ayaa si tartiib tartiib ah u kordheysa 4-8 saacadood ka dib dhaawaca myocardial, qiimaha ugu sarreeyana wuxuu soo baxaa 12-24 saacadood. troponin wadnaha oo sarreeya ayaa weli lagu ogaan karaa dhiigga ku wareegsan 7-10 maalmood ka dib dhaawaca myocardial.
Creatine kinase isoenzyme hadda waa "heerka dahabka" ee baaritaanka AMI ee ay dhakhaatiirtu aad ugu kalsoon yihiin, waxayna leedahay gaar gaar ah. Isku darka ogaanshaha troponin wadnaha I (cTnI), creatine kinase isoenzyme (CKMB) iyo myoglobin (myo) ayaa leh dareen wanaagsan iyo gaar ahaan, taasoo ka dhigaysa ogaanshaha mid sax ah. Si loo gaaro ogaanshaha hore, daawaynta hore, si loo yareeyo ogaanshaha la seegay iyo waqtiga saxda ah ee khatarta bukaanka.
Alaabtatafatiran
Faa'iidada alaabta:
Dareenka sare: cTnI In ka yar ama la mid ah 0.1 ng/mL; CKMB In ka yar ama la mid ah 0.1 ng/mL; Myo In ka yar ama la mid ah 2.5 ng/mL
Kala duwanaansho toosan oo ballaaran: cTnI (0.1-30 ng/mL); CKMB ({1} ng/mL); Myo (5-400 ng/ml)
Waqtiga falcelinta degdega ah: 15 min
Waqtiga ogaanshaha degdega ah: 7 s
Halbeegyada waxqabadka:
Nooca muunada: serum, plasma iyo dhiiga oo dhan
Saxnimada: CV ka yar ama la mid ah 15%
Qiimaha tixraaca: cTnI＜0.3 ng/mL; CKMB 5 ng/ml; Myo 55 ng/ml
Tijaabada isbarbardhigga: Ogaanshaha cTnI ee Beckman Chemiluminescence, isku xidhka R2
gaadhay 0.9779; Xidhiidhka R² ee CKMB wuxuu gaadhay 0.9866; Xidhiidhka R² of Myo ayaa gaadhay
0.9835
Codsiga caafimaad:
Wadnaha wadnaha oo ba'an
Dhaawac muruqa qalfoofka ah
angina pectoris oo aan degganayn
Dhaawaca wadnaha wadnaha
Polymyositis
Rhabdomyolysis
Waaxyaha la dabaqay
Waxay khusaysaa waaxda wadnaha, waaxda degdega ah, shaybaadhka, qalliinka, dhakhtarka carruurta, kansarka, unugga daryeelka degdegga ah, unugga daryeelka degdegga ah (ICU), hematology iyo waaxyo kale.
FAQ
S: Waa maxay xirmadan tijaabada ah ee saddex-geesoodka ah, maxayse tahay faa'iidada ugu weyn ee ay leedahay?
J: Qalabka Tijaabada Degdegga ah ee Saddex-geesoodka Wadnaha waa qalab goyn - cidhifka in vitro-ga qalabka kaas oo isku mar iyo tiro ahaan cabbiraya saddex biomarkers oo muhiim u ah Wadnaha Wadnaha Wadnaha (AMI): Wadnaha Troponin I (cTnI), Creatine Kinase Isoenzyme MB (CK-MB) Faa'iidada ugu muhiimsan waa in la helo muuqaal wadnaha oo dhammaystiran oo hal muunad ah oo keliya hal tijaabo ah, taasoo si weyn u caawinaysa ogaanshaha degdegga ah ee saxda ah ee wadne xanuunka.
S: Maxay tahay sababta tijaabada dhammaan saddexda calaamadood (cTnI, CK-MB, iyo Myoglobin) ay muhiim u tahay?
J: biomarker kastaa wuxuu bixiyaa xog gaar ah, oo dhamaystiran oo leh waqtiyo kala duwan oo la sii daayo:
Myoglobin: Wuxuu u kacaa marka hore (1{1}}3 saacadood gudahood), aad ayuu ugu fiican yahay ka saarida hore sababtoo ah saadaasha xun ee saraysa.
CK -MB: Wuxuu kacaa 3{2}}6 saacadood gudahood wuxuuna ka badan yahay wadnaha{4}} oo ka gaar ah myoglobin. Waxay faa'iido u leedahay in la ogaado dib-u-warshadaynta.
cTnI: "Heerka dahabka" ee ogaanshaha AMI. Waxay kor u kacdaa 3-6 saacadood gudahood waxayna ahaanaysaa mid sare u kacday maalmo, taas oo siinaya khaas ah dhaawac muruqa wadnaha ah.
Tijaabinta dhammaan saddexda si wadajir ah waxay dabooshaa dhammaan dariishada hore ee ogaanshaha waxayna wanaajisaa kalsoonida bukaan-socodka.
S: Ma bixisaa falanqeeyaha immunoassay ee fluorescence?
J: Haa, waxaanu bixinaa isticmaale{0}saaxiibtinimo, iyo falanqeeyeyaal la qaadan karo oo fluorescence immunoassay ah. Waxa jira hal kanaal iyo 12 - kanaal falanqeeye. Waxay muujinayaan kaydinta xogta, fursadaha isku xidhka, iyo hawlgalka fudud, taas oo ka dhigaysa mid ku habboon labada shaybaadhka iyo barta - isticmaalka daryeelka. Fadlan tixraac faahfaahinta alaabtayada ee liiska alaabta.
Hot Tags: ctni / ck-mb / xirmada tijaabada myo, China ctni / ck{1}}mb / myo qalabyada soo saarayaasha, alaab-qeybiyeyaal
